However, the findings of the connection between laboratory investigation and CSDH recurrence are still scarce.īlood urea nitrogen (BUN) concentration is an easily overlooked investigation. įactors found to influence CSDH recurrence have been reported in several studies, including age, Glasgow coma score (GCS), antiplatelet or anticoagulant agents, bilateral hematomas, postoperative pneumocephalus, and other certain related computed tomography (CT) findings. Burr-hole irrigation (BHI) is most widely used to treat CSDH with a relatively good outcome, but about 2–31% of patients relapse after the initial operation. The incidence of CSDH is estimated to be 8.2–17.6 per 100,000 persons per year which increases along with increasing age. ConclusionsĮlevated BUN at post-operation is significantly associated with the recurrence of CSDH, and it is indicated that high levels of serum BUN after evacuation may serve as a risk factor for CSDH recurrence.Ĭhronic subdural hematoma (CSDH) is a frequently encountered neurosurgical disorder that is common among the aged. In multiple-adjusted spline regression, a high BUN level visually showed a significantly high OR value of recurrence risk. After adjusting for the potential confounders, the odds ratio of recurrence was 3.069 (95%CI =1.488–6.330, p = 0.002) for the highest quartile of BUN compared with the lowest quartile. Significant distinctions were found between recurrence and non-recurrence groups in postoperative BUN quartiles of cases ( P = 0.003). ResultsĬSDH recurrence was observed in 96 (14.7%) cases.
Restricted cubic spline regressions and logistic regression models were performed to estimate the effect of BUN on CSDH recurrence. The cases were divided into recurrence and non-recurrence groups while postoperative BUN concentration was further separated into quartiles (Q1 ≤ 4.0 mmol/L, 4.0 6.4 mmol/L). The analyzed parameters included age, gender, comorbidities, laboratory investigations, medication use and hematoma location. MethodsĪ total of 653 CSDH cases with Burr-hole Irrigation (BHI) were enrolled from December 2014 to April 2019. Therefore, this paper attempts to show the relationship between BUN and CSDH recurrence. Recently, there has been renewed interest in the association between Blood Urea Nitrogen (BUN) and intracranial lesion. Chronic subdural hematoma (CSDH) is fundamentally treatable with about a 2–31% recurrence rate.
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